Phytochemicals: an immune booster against the pathogens

Phytochemicals are chemical compounds produced by plants. Actually, it is produced by primary and secondary metabolism. Vegetables, fruits, whole grains, nuts, seeds, etc., are rich with phytochemicals and impart aroma, colors, and flavors. There are many phytochemicals like polyphenols, flavonoids, carotenoids, phytoestrogens, phytosterols, etc. They act as antioxidants against diseases related to lungs, urinal, stomach, and heart and can be used as nutraceuticals to control various metabolic disorders. Medicinal plants have been regarded as beneficial for many centuries. In India, Himalayas and Western Ghat regions are diverse in such plants. It has many beneficial effects on human health and boosts up immunity. Tens of thousands of phytochemicals have been identified, and many more are yet to be discovered. Synthetic medicine is known to cause many side effects on human health, and having such natural medicinal plants in diet is believed to be beneficial without side effects. They may increase immunity to fight against today's diseases like SARS, MERS, and Coronavirus (CoV) infections. The phytotherapy or the phytomedicines are effective immunity boosters and have the potential to eliminate bacterial as well as viral infections. Phytochemicals like phenolic compounds, vegetables, and fruits containing such compounds in the human diet may be effective against coronaviruses and people cure due to having it in their diet too. Still more research and identification of such compounds are required to get more information regarding its benefits. The phytotherapy-based research and developing phytotherapic medicines could cure many more chronic as well as acute diseases. This chapter deals with comprehensive information on phytochemicals and its importance. © 2023 Elsevier Inc. All rights reserved.

Bioactive compounds in Layacha brown rice (Oryza sativa L.) improve immune responses in mice via activation of transcription factor Nrf2

Dysregulated or weak immunity is caused by ageing, chemo-radiotherapy, COVID-19, infections, steroids, pollutants and toxins. Bioactive foods are required for boosting immunity. In the present study, nine rice (Oryza sativa L.) varieties were selected from the repository of 23,250 Indian germplasm accessions. The immunomodulatory effects of these rice varieties were assessed in vitro and in vivo. Layacha-rice-methanolic-extract (Larimex) significantly enhanced innate (>20%) and adaptive (>10%) immune responses evinced from higher bacterial phagocytosis by macrophages, increased mitogen-induced T-cell proliferation (11%) and scavenged reactive oxygen species (ROS) (70–80%). Larimex activated transcription factor Nrf2 and its downstream genes Nqo1, Ho1 and Txnrd1 in immune cells. Larimex significantly improved immune responses (>20%) only in cells from wild type but not Nrf2 knock-out mice indicating its causal role in boosting immunity. Untargeted metabolomics of Layacha rice showed preponderance of metabolic pathways and bioactive compounds, which activate Nrf2 in mammalian cells. Layacha rice can be a suitable food for boosting immunity.

Clinically proven natural products, vitamins and mineral in boosting up immunity: A comprehensive review.

Background: and Purposes: The terminology "immune boost-up" was the talk of the topic in this Covid-19 pandemic. A significant number of the people took initiative to increase the body's defense capacity through boosting up immunity worldwide. Considering this, the study was designed to explain the natural products, vitamins and mineral that were proved by clinical trail as immunity enhancer. Methods: Information was retrieved from SciVerse Scopus ® (Elsevier Properties S. A, USA), Web of Science® (Thomson Reuters, USA), and PubMed based on immunity, nutrients, natural products in boosting up immunity, minerals and vitamins in boosting up immunity, and immune booster agents. Result: A well-defined immune cells response provide a-well functioning defense system for the human physiological system. Cells of the immune system must require adequate stimulation so that these cells can prepare themselves competent enough to fight against any unintended onslaught. Several pharmacologically active medicinal plants and plants derived probiotics or micronutrients have played a pivotal role in enhancing the immune boost-up process. Their role has been well established from the previous study. Immune stimulating cells, especially cells of acquired immunity are closely associated with the immune-boosting up process because all the immunological reactions and mechanisms are mediated through these cells. Conclusion: This article highlighted the mechanism of action of different natural products, vitamins and mineral in boosting up the immunity of the human body and strengthening the body's defense system. Therefore, it is recommended that until the specific immune-boosting drugs are available in pharma markets, anyone can consider the mentioned products as dietary supplements to boost up the immunity.

A CROSS-SECTIONAL STUDY: PERCEPTION AND CONSUMPTION BEHAVIOR ABOUT IMMUNITY BOOSTER SAMBUCUS SP. PRODUCTS (AZERBAIJAN, GEORGIA, UZBEKISTAN)

Objective: The aim of this cross-sectional study was to measure and determine the difference between perception and consumption changes of elderberry products in Azerbaijan (AZ), Georgia (GEO) and Uzbekistan (UZB) countries. Material and Method: A questionnaire based, cross-sectional, multi country study was conducted by using an online based with consumers of pharmacies, drug stores and shops where had food supplement category between April and August 2021. Result and Discussion: The majority of responders belong to 31-50 age group, and higher gender profile was on female part, 85%. The results showed that end users of consumed products were children (51%) and older family members (39%) in the average data of 3 countries. Elderberry products were classified as expensive products but were consumed high amount during the pandemic. During the pandemic, immune boosting had been in prior place of individual healthcare, and prophylactic approach had become more important than earlier. This is the first study in Azerbaijan, Georgia and Uzbekistan as a digital survey based, cross- sectional study. © 2022 Authors. All rights reserved.

Herbal Drugs as Immune Booster Against Viral Infections

The immune system involves both active and passive immunization. The antibodies are developed against the antigens during active immunization and are permanently stored. But, in the case of passive immunization, the antibodies are exposed to the same antigens in every person who is already infected. In order to enhance the immune systems i.e. innate and adaptive immune responses, herbal plants are used as an immune booster. Some of the herbal plants have been proven clinically to enhance immunity that includes Morniga oleifera (Drumstick), Azadirachta indica (Neem), Ocimum sanctum (Tulsi), Withania somnifera (Aswagandha), Zingiber officinale (Ginger), Allium sativum (Garlic), Curcuma longa (Turmeric), Emblica officinalis (Amla) etc. Compared to synthetic drugs, herbal drugs have fewer side effects and stimulate the immune system to defend against various foreign pathogens. Even though herbal medicines are usually considered as safe and effective therapy, it is clinically proven that if a drug is effective, it would have some side effects. But, sometimes, the antioxidant property of herbal medicines is helpful in reducing the toxicities produced by any toxic substances or any drugs. This review aims to encourage the study of various herbal constituents and their role in the treatment of different types of viral infections.

Development of Salmon Protein Based Shelf Stable Snacks and Improving Their Storage Quality Using Solanum nigrum, a Natural Immune Booster

The aim of the present study was to develop salmon protein-based shelf stable snacks and to improve their storage quality using Solanum nigrum extract. The products were developed by incorporating different levels of salmon protein powder viz. 20% (T-1), 30% (T-2), 40% (T-3), and 0.0% (control). The snacks containing optimum level of protein powder (30%) were incorporated with S. nigrum extract (1.0%) and stored at room temperature (25 +/- 1 degrees C) for 75 days. Incorporation of salmon protein powder significantly increased the protein and fat contents and decreased the carbohydrate content. The snacks containing 30% salmon protein powder showed highest scores for all sensory characteristics. The total phenolic content and DPPH-radical scavenging (% inhibition) of S. nigrum extract was 380 mg GAE/100 g and 79.0, respectively. Addition of S. nigrum extract significantly (P < .05) improved the lipid stability (reduced TBARS and free fatty acids) and microbial quality (total-plate and yeast/moulds), while enhancing the sensory quality of the snacks during storage. Salmon protein powder and S. nigrum can be used for the development of highly nutritive shelf stable snacks with improved lipid oxidative and microbial stability. The immune boosting properties of S. nigrum can be of health importance during this pandemic of SARS-CoV-2.

Andrographolide: A Herbal-Chemosynthetic Approach for Enhancing Immunity, Combating Viral Infections, and Its Implication on Human Health.

Plants consistently synthesize and accumulate medically valuable secondary metabolites which can be isolated and clinically tested under in vitro conditions. An advancement with such important phytochemical production has been recognized and utilized as herbal drugs. Bioactive andrographolide (AGL; C20H30O5) isolated from Andrographis paniculate (AP) (Kalmegh) is a diterpenoid lactones having multifunctional medicinal properties including anti-manic, anti-inflammatory, liver, and lung protective. AGL is known for its immunostimulant activity against a variety of microbial infections thereby, regulating classical and alternative macrophage activation, Ag-specific antibody production during immune disorder therapy. In vitro studies with AGL found it to be effective against multiple tumors, neuronal disorders, diabetes, pneumonia, fibrosis, and other diverse therapeutic misadventures. Generally, virus-based diseases like ZIKA, influenza A virus subtype (H1NI), Ebola (EBOV), Dengue (DENV), and coronavirus (COVID-19) epidemics have greatly increased scientific interest and demands to develop more effective and economical immunomodulating drugs with minimal side effects. Trials and in vitro pharmacological studies with AGL and medicinally beneficial herbs might contribute to benefit the human population without using chemical-based synthetic drugs. In this review, we have discussed the possible role of AGL as a promising herbal-chemo remedy during human diseases, viral infections and as an immunity booster.

Altered immunoemotional regulatory system in COVID-19: From the origins to opportunities.

The emergence of the novel coronavirus (SARS-CoV-2) and the worldwide spread of the coronavirus disease (COVID-19) have led to social regulations that caused substantial changes in manners of daily life. The subsequent loneliness and concerns of the pandemic during social distancing, quarantine, and lockdown are psychosocial stressors that negatively affect the immune system. These effects occur through mechanisms controlled by the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenocortical (HPA) axis that alter immune regulation, namely the conserved transcriptional response to adversity (CTRA), which promotes inflammation and diminishes antiviral responses, leading to inadequate protection against viral disease. Unhealthy eating habits, physical inactivity, sleep disturbances, and mental health consequences of COVID-19 add on to the pathological effects of loneliness, making immunity against this ferocious virus an even tougher fight. Therefore, social isolation, with its unintended consequences, has inherently paradoxical effects on immunity in relation to viral disease. Though this paradox can present a challenge, its acknowledgment can serve as an opportunity to address the associated issues and find ways to mitigate the adverse effects. In this review, we aim to explore, in detail, the pathological effects of the new social norms on immunity and present suggested methods to improve our physical, psychological, and healthcare abilities to fight viral infection in the context of the COVID-19 pandemic.

Swarna Bindu Prashana-an Ancient Approach to Improve the Infant's Immunity.

Swarna bindu prashana (SBP) is a metallic medicinal preparation widely used in Ayurveda pediatrics. The main ingredients of SBP are swarna prashan (gold nanoparticle), gou ghrita (cow ghee), madhu (honey), and other medhya dravyas (drugs which enhance intellectual, memory). According to the Indian classical text, SBP has been proposed as a potent medicine for immunotherapies and vaccine development due to its indefinite size, shapes, charges, and surface functionality. In this review, we describe the plausible mechanism of SBP in dendritic cells maturation and subsequent T cell activation. But being herbo-metallic preparation, its safety and efficacy are well supported by the classical publications of Ayurveda. To conclude, SBP is an immune booster for infants against any viral disease, and it is necessary to validate its safety and efficacy through systematic methodological research.

Prospective options of algae-derived nutraceuticals as supplements to combat COVID-19 and human coronavirus diseases.

The outbreak of the coronavirus disease of 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 that has created huge trepidation worldwide, has a mortality rate of 0.5% to 1% and is growing incessantly. There are currently no therapies and/or vaccines that may help abate this viral disease, but the use of masks and social distancing can limit the spread. Boosting immunity has been a simple way to resist viral infection and limit fatalities. In this context, the use of nutraceuticals appears to be a potential panacea. The ability of algae-based nutraceuticals, mainly Spirulina, to boost immunity against viral diseases has already been reported clinically. Spirulina-based nutraceuticals boost the adaptive and innate immunity, and bioactive compounds, such as angiotensin-converting enzyme (ACE) inhibitor peptides, phycobiliproteins, sulfated polysaccharides, and calcium-Spirulan, can serve as antiviral agents. The presence of these molecules indicates its potential role in resisting infection and COVID-19 disease progression. This review focuses on the potential role of algal nutraceuticals as immune boosters to combat the human coronavirus and other viral diseases. The potential use of Spirulina-based nutraceuticals for combating COVID-19, its mechanism, and future directions have also been discussed.